| Autor: |
de Vrij, Jeroen, Willemsen, Ralph, Lindholm, L, Hoeben, RC |
| Přispěvatelé: |
Neurosurgery, Medical Oncology |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Human Gene Therapy, 21(7), 795-805. Mary Ann Liebert Inc. |
| ISSN: |
1043-0342 |
| Popis: |
Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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