Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia
| Autor: | de Jong, Daniëlle, Jansen, René W M M, Kremer, H P H, Verbeek, Marcel M |
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| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Analysis of Variance Amyloid beta-Peptides Dementia Vascular Research Support Non-U.S. Gov't tau Proteins Middle Aged Sensitivity and Specificity Diagnosis Differential ROC Curve Alzheimer Disease mental disorders Journal Article Humans Female Comparative Study cardiovascular diseases Phosphorylation Biomarkers Aged |
| Zdroj: | Journal of Gerontology: Medical sciences, 61(7), 755-758. Oxford University Press |
| ISSN: | 1079-5006 |
| Popis: | BACKGROUND: The differentiation of Alzheimer's disease (AD) from vascular dementia (VaD) is hampered by clinical diagnostic criteria with disappointing sensitivity and specificity. The objective of this study was to investigate whether cerebrospinal fluid (CSF) levels of total tau protein (t-tau), amyloid beta42 protein (Abeta42), and tau phosphorylated at threonine 181 (p-tau181) are useful biomarkers to distinguish AD patients from VaD patients. METHODS: We measured CSF levels of p-tau181, Abeta42, and t-tau in 86 patients with a clinical diagnosis of AD or VaD and in 30 control participants. RESULTS: Optimal differentiation between AD and VaD was achieved by using the ratio of the CSF levels of Abeta42 and p-tau181 (Q Abeta42/p-tau) with sensitivity, specificity, positive and negative predictive values all > or = 85%. CONCLUSIONS: Our results support further efforts to prospectively validate the use of Q Abeta42/p-tau as a biomarker to discriminate between AD and VaD. |
| Databáze: | OpenAIRE |
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