| Autor: |
Koene, H. R., Biemond, B. J., van der Schoot, C. E. |
| Přispěvatelé: |
Clinical Haematology, Amsterdam institute for Infection and Immunity, Cancer Center Amsterdam, Landsteiner Laboratory |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Nederlands tijdschrift voor geneeskunde, 151(32), 1784-1787. Bohn Stafleu van Loghum |
| ISSN: |
0028-2162 |
| Popis: |
The identification of a point mutation in the JAK2 gene in most patients with polycythaemia vera (PV) has led to increased insight into the pathogenesis of the disease. The mutation causes cytokine-independent growth and proliferation of haematopoietic precursor cells, leading to erythrocytosis. The JAK2-V617F mutation is present in 65-97% of PV-patients and, when found, is indicative for the disease. Future research will have to show if the mutated gene can serve as a target for specific, antiproliferative therapy |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
