Increased LCAT activity and hyperglycaemia decrease the antioxidative functionality of HDL
| Autor: | Kappelle, Paul J.W.H., de Boer, Jan Freark, Perton, Frank G., Annema, Wijtske, de Vries, Rindert, Dullaart, Robin P. F., Tietge, Uwe J. F. |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
HDL function
HDL APOLIPOPROTEIN-A-I THERAPEUTIC TARGET type 2 diabetes mellitus LECITHIN-CHOLESTEROL ACYLTRANSFERASE Cholesterol glucose nutritional and metabolic diseases TYPE-2 DIABETES-MELLITUS DIET-INDUCED ATHEROSCLEROSIS lipoproteins MICE CARDIOVASCULAR-DISEASE lipids (amino acids peptides and proteins) OXIDATIVE STRESS HIGH-DENSITY-LIPOPROTEIN DEFICIENCY SYNDROMES |
| Zdroj: | European Journal of Clinical Investigation, 42(5), 487-495. Wiley |
| ISSN: | 0014-2972 |
| Popis: | Background Type 2 diabetes mellitus increases the risk of atherosclerotic cardiovascular disease. Antioxidative properties of high density lipoprotein (HDL) are important for atheroprotection. This study investigated whether the antioxidative functionality of HDL is altered in type 2 diabetes mellitus and aimed to identify potential determinants of this parameter. Materials and methods In a cross-sectional study, we investigated 74 patients with type 2 diabetes and 75 control subjects. Antioxidative properties of HDL were measured and expressed as either (i) HDL antioxidative capacity or (ii) HDL antioxidation index after multiplying HDL antioxidative capacity results with individual plasma HDL cholesterol concentrations. Lecithin:cholesterol acyltransferase (LCAT) and paraoxonase-1 (PON-1) activities were determined. Results HDL antioxidative capacity was similar in patients with diabetes and controls, while the HDL antioxidation index was decreased in patients with diabetes (P = 0.005) owing to lower plasma HDL cholesterol (P |
| Databáze: | OpenAIRE |
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