Salt sensitivity correlates positively with insulin sensitivity in healthy volunteers
| Autor: | ter Maaten, JC, Voordouw, JJ, Bakker, SJL, Gans, ROB |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
blood pressure
BLOOD-PRESSURE DIABETES-MELLITUS DENSITY LIPOPROTEIN CHOLESTEROL PUBERTAL DEVELOPMENT uric acid NORMOTENSIVE SUBJECTS VASCULAR REACTIVITY high-density lipoprotein cholesterol salt sensitivity SERUM URIC-ACID euglycaemic clamp CARDIOVASCULAR RISK-FACTORS insulin sensitivity ESSENTIAL-HYPERTENSION RESISTANCE |
| Zdroj: | European Journal of Clinical Investigation, 29(3), 189-195. Wiley |
| ISSN: | 0014-2972 |
| Popis: | Background The aim of the study was to assess the relationship between insulin sensitivity and salt sensitivity in healthy subjects who display a wide range of insulin sensitivity. As a secondary objective, we assessed the relationship between salt sensitivity and the other characteristics of the insulin resistance syndrome. Study design Forty-seven normotensive volunteers (age 34 +/- 15 years) with a normal glucose tolerance test were selected. We measured insulin sensitivity using the hyperinsulinaemic euglycaemic clamp (50 mUkg(-1)h(-1)), blood pressure, waist-to-hip ratio, fasting insulin levels, serum lipids and uric acid levels. In a subset of 21, representing a wide range of insulin sensitivity, salt sensitivity was determined as the difference in mean arterial blood pressure (MAP) at the end of a high-salt diet (10 g of NaCl per day for 1 week) vs. a low-salt diet (2 g of NaCl per day for 1 week). Results Insulin sensitivity (MII value, range 0.49-4.41 mgkg(-1)min(-1) per pmol L-1 x 100) was negatively correlated with MAP (r = -0.54, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text