| Autor: |
van Munster, Sanne, Nieuwenhuis, Esther, Bisschops, R, Willekens, H, Weusten, Bas L A M, Herrero, Lorenza Alvarez, Bogte, Auke, Alkhalaf, Alaa, Schenk, B E, Schoon, Erik J, Curvers, Wouter, Koch, Arjun D, de Jonge, Pieter Jan F, Tang, Tjon J, Nagengast, Wouter B, Westerhof, Jessie, Houben, Martin H M G, Bergman, Jacques J G H M, Pouw, Roos E |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Zdroj: |
Clinical Gastroenterology and Hepatology. ELSEVIER SCIENCE INC |
| ISSN: |
1542-3565 |
| Popis: |
BACKGROUND AND AIMS: Endoscopic eradication therapy (EET) for Barrett's esophagus (BE) related neoplasia is safe and leads to complete eradication in the majority of patients. However, a subgroup will experience a more complex treatment course with a risk for failure or disease progression. Early identification of these patients may improve patient counseling and treatment outcomes. We aimed to develop a prognostic model for such complex treatment course. METHODS: We collected data from a nationwide registry that captures outcomes for all patients undergoing EET for early BE neoplasia. A complex treatment course was defined as neoplastic progression, treatment failure, or need for endoscopic resection during RFA treatment phase. We developed a prognostic model using logistic regression. We externally validated our model in an independent registry. RESULTS: A total of 1,356 patients were included of which 78 (6%) had complex treatment course. Our model identified patients with BE length ≥9cm with a visible lesion containing HGD/cancer; and patients with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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