| Autor: |
de Rijk-van Andel, J. F., Arts, W. F., Barth, P. G., Loonen, M. C. |
| Přispěvatelé: |
Other departments |
| Jazyk: |
angličtina |
| Rok vydání: |
1990 |
| Zdroj: |
Developmental medicine and child neurology, 32(8), 707-717. Wiley-Blackwell |
| ISSN: |
0012-1622 |
| Popis: |
Lissencephaly type I has been described as either the cerebral expression of a complex malformation syndrome such as Miller-Dieker syndrome (MDS), or as isolated lissencephaly sequence (ILS). In a nation-wide study in The Netherlands, of 21 patients with lissecephaly type I, four were found to have MDS and 17 ILS. New clinical aspects were as follows: the mean life-span of the entire group was longer than previously reported; patients with lissencephaly grades 3 or 4 (mixture of agyria and pachygyria, or complete pachygyria) developed seizures later than those with grades 1 and 2 (complete and almost complete agyria); microcephaly was not always present in patients with grades 3 and 4 lissencephaly; and patients with lissencephaly grades 1 and 2 had hardly any psychomotor development, while those with grades 3 and 4 were severely retarded |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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