| Autor: |
ZWEIPFENNING, PGM, WILDERINK, AHCM, HORSTHUIS, P, FRANKE, JP, DEZEEUW, RA |
| Přispěvatelé: |
Groningen Research Institute of Pharmacy |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Journal of Chromatography A, 674(1-2), 87-95. ELSEVIER SCIENCE BV |
| ISSN: |
0021-9673 |
| Popis: |
The application of Bond-Elut Certify solid-phase extraction columns to the systematic toxicological analysis of whole blood was evaluated. The reproducibility of the extraction was tested with thirteen drugs varying in physico-chemical properties. Analysis was performed with capillary gas chromatography with nitrogen-selective detection. The recoveries were reproducible, as long as other limiting factors, e.g., chromatographic behaviour or volatility, do not play a significant role. The effect of limiting chromatographic behaviour was studied in more detail with the more sensitive mass spectrometry with selected-ion monitoring after converting the extracted morphine into its ditrimethylsilyl derivative. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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