| Autor: |
Wirds, J W, Duyn, A E J, Geraerts, S D, Preijer, E, Van Diemen-Steenvoorde, J A A M, Van Leeuwen, J H Schagen, Haas, F J L M, Gerritsen, W B M, De Boer, A, Leusink, J A, Dep Farmaceutische wetenschappen, Sub Pharmacotherapy, Theoretical, Emeriti TLC |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Archives of Disease in Childhood Fetal and Neonatal Edition, 88(1), F67. BMJ Publishing Group Ltd |
| ISSN: |
1359-2998 |
| Popis: |
BACKGROUND: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system. OBJECTIVE: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery. METHOD: S100 protein levels in umbilical cord blood of 81 healthy infants were determined. RESULTS: S100 protein was present in arterial (median concentration 1.62 micro g/l) and venous (median concentration 1.36 micro g/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 micro g/l; median venous concentration 1.48 micro g/l) than births by caesarean section (1.51 micro g/l and 1.26 micro g/l respectively). CONCLUSION: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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