| Autor: |
Franssen, EJF, van Essen, GG, Portman, AT, Go, G, Stegeman, CA, Uges, DRA |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute of Pharmacy, Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR) |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Therapeutic Drug Monitoring, 21(3), 289-292. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: |
0163-4356 |
| Popis: |
The toxicity and pharmacokinetic properties of a drug determine whether hemodialysis and/or hemoperfusion are indicated in acute intoxications. Valproic acid is considered unremovable by hemodialysis because of the high protein binding of 90%-95%. A 27-year-old male with a history of seizures was admitted to the emergency room because of coma, hypernatriemia, and respiratory failure caused by an intoxication with a large dose of valproic acid. At admission; the plasma valproic acid level was 1414 mg/L (9.9 mmol/L) (therapeutic range: 50-100 mg/L (350-700 umol/L). The anion gap was 26 mmol/L (normal |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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