| Autor: |
Schwingenschuh, Petra, Saifee, Tabish A., Katschnig-Winter, Petra, Macerollo, Antonella, Koegl-Wallner, Mariella, Culea, Valeriu, Ghadery, Christine, Hofer, Edith, Pendl, Tamara, Seiler, Stephan, Werner, Ulrike, Franthal, Sebastian, Maurits, Natasha M., Tijssen, Marina A., Schmidt, Reinhold, Rothwell, John C., Bhatia, Kailash P., Edwards, Mark J. |
| Přispěvatelé: |
Movement Disorder (MD), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Movement Disorders, 31(4), 555-562. Wiley |
| ISSN: |
0885-3185 |
| Popis: |
BackgroundIn a small group of patients, we have previously shown that a combination of electrophysiological tests was able to distinguish functional (psychogenic) tremor and organic tremor with excellent sensitivity and specificity. ObjectivesThis study aims to validate an electrophysiological test battery as a tool to diagnose patients with functional tremor with a laboratory-supported level of certainty. MethodsFor this prospective data collection study, we recruited 38 new patients with functional tremor (mean age 37.924.5 years; mean disease duration 5.99.0 years) and 73 new patients with organic tremor (mean age 55.4 +/- 25.4 years; mean disease duration 15.8 +/- 17.7 years). Tremor was recorded at rest, posture (with and without loading), action, while performing tapping tasks (1, 3, and 5Hz), and while performing ballistic movements with the less-affected hand. Electrophysiological tests were performed by raters blinded to the clinical diagnosis. We calculated a sum score for all performed tests (maximum of 10 points) and used a previously suggested cut-off score of 3 points for a diagnosis of laboratory-supported functional tremor. ResultsWe demonstrated good interrater reliability and test-retest reliability. Patients with functional tremor had a higher average score on the test battery when compared with patients with organic tremor (3.6 +/- 1.4 points vs 1.0 +/- 0.8 points; P ConclusionWe now propose this test battery as the basis of laboratory-supported criteria for the diagnosis of functional tremor, and we encourage its use in clinical and research practice. (c) 2016 International Parkinson and Movement Disorder Society |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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