| Autor: |
SPRONK, P.E., Bootsma, H., HUITEMA, M.G., Limburg, Piet, Kallenberg, Cees |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Translational Immunology Groningen (TRIGR) |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Clinical and Experimental Immunology, 97(3), 439-444. Wiley |
| ISSN: |
0009-9104 |
| Popis: |
Active SLE is characterized by immune deposits and subsequent vascular inflammation in many organs. Expression and up-regulation of adhesion molecules is basic to migration of inflammatory cells into the tissues. Recently, soluble isoforms of these molecules have been described which might be an expression of their up-regulation in the tissues and, as such, of disease activity. The purpose of this study was to evaluate whether changes in levels of soluble adhesion molecules reflect disease activity. We analysed serial sera in a 6-month period preceding 22 consecutive exacerbations of SLE for levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), and sE-selectin. Levels were related to clinical disease activity (SLEDAI), and levels of anti-dsDNA and complement. At the time of maximal disease activity, levels of sVCAM-1 in patients with SLE were higher than those in controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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