| Autor: |
WEIJERS, RNM, LAWSON, C, LEUNISSEN, J |
| Jazyk: |
angličtina |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
European journal of clinical chemistry and clinical biochemistry, 30(8), 449-454 |
| ISSN: |
0939-4974 |
| Popis: |
Macro enzymes, i. e. complexes of normal (iso-)enzymes with an immunoglobulin, may be due to immunological cross-reactions evoked by specific viral antigenic determinants that are homologous to regions in the target enzymes. A search of the National Biomedical Research Foundation protein databank with the amino-acid sequence of human pancreatic amylase revealed a marked homology with a fragment of the yellow fever virus major envelope protein E: i. e. an overall identity of 19.7 per cent and a high degree (40.9 per cent) of conservative amino-acid substitutions over 119 amino acids. At each identical position, the corresponding residue of Taka amylase A was examined by three-dimensional structure analysis, to determine whether the position is likely to be buried or exposed. The existence of a site (epitope) on amylase recognized by an anti-amylase antibody is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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