| Autor: |
VANLITH, JMM, MANTINGH, A, DEBRUIJN, HWA, KLOOSTERMAN, MD, KANHAI, HHH, WOLF, H, EVERHARDT, E, CHRISTIAENS, GCML |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Prenatal Diagnosis, 13(12), 1123-1131. Wiley-Blackwell |
| ISSN: |
0197-3851 |
| Popis: |
We measured the maternal serum cancer antigen 125 (MS-CA 125) levels in 98 nonpregnant women, 765 first- and second-trimester pregnancies with chromosomally-normal fetuses, and 54 chromosomally-abnormal pregnancies. To determine the MS-CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter-assay variability. The median MS-CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non-pregnant women. We found no difference between normal and Down's syndrome (n=29) pregnancies (t-test: t=0.57, p>0.5). The MS-CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS-CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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