| Autor: |
BREED, ASPM, MANTINGH, A, VOSTERS, R, BEEKHUIS, [No Value], VANLITH, JMM, ANDERS, GJPA |
| Jazyk: |
angličtina |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Prenatal Diagnosis, 11(8), 577-580. Wiley-Blackwell |
| ISSN: |
0197-3851 |
| Popis: |
In 2103 consecutive diagnostic chorionic villus samples, examined in a 4-year period in our clinical genetics unit, 26 samples (1.2 per cent) presented chromosomal mosaicism in the direct and/or long-term culture preparations. Only once (46,XX/47,XX,+9) was the mosaicism confirmed in the fetus. In the cytogenetic follow-up studies of the remaining 25 pregnancies, in no cases could the aberration be confirmed in amniotic fluid or fetal tissue. One patient requested a termination after the CVS result. Of the remaining 24 pregnancies, four (16.7 per cent) ended in a spontaneous abortion. These findings suggest an association between placental mosaicism and fetal loss. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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