CGMP as second messenger during Dictyostelium chemotaxis
| Autor: | Van Haastert, PJM, Roelofs, J, Kuwayama, H, Thiery, JP |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING, 134-141 STARTPAGE=134;ENDPAGE=141;TITLE=MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING |
| Popis: | The chemoattractant cAMP induces directed cell locomotion in Dictyostelium cells. Several second messenger pathways are activated upon binding of cAMP to G-protein-coupled receptors, inducting adenylyl cyclase, guanylyl cyclase, phospholipase C, and the opening of plasma membrane Ca2+ channels. These second messenger responses are unaltered in many chemotactic mutants, except for the cGMP response. Activation of guanylyl cyclase depends on G-proteins and is regulated by a cGMP-binding protein in a complex manner. This cGMP-binding protein also mediates intracellular functions of cGMP to activate a PKC related kinase that phosphorylates myosin II heavy chain, thereby allowing myosin filaments to rearrange during cell movement. |
| Databáze: | OpenAIRE |
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