| Autor: |
Zwinkels, H, Roon, K, Jeurissen, FJF, Taphoorn, MJB, Hop, Vecht, CJ |
| Přispěvatelé: |
Epidemiology, Neurology |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Oncology Nursing Forum, 36(2), 225-231. Oncology Nursing Society |
| ISSN: |
0190-535X |
| Popis: |
Purpose/Objectives: To investigate the toxicity of temozolomide (TMZ) in patients with brain tumors and appropriate nursing interventions. Design: Explorative analysis of prospective data. Setting: A IMZ clinic led by a nurse practitioner (NP). Sample: Group A (n = 71) received a standard close of Tmz daily for five clays 200 mg/m(2) every four weeks; group B (n = 19) received a close-intense schedule of TMZ daily for 21 clays 75 mg/m(2) every four weeks. Methods: Toxicities were scored according to National Cancer Institute Common Terminology Criteria, and results in the two groups were compared, Main Research Variables: Thrombopenia, neutropenia, and lymphopenia; nausea and vomiting; and NP interventions. Findings: of observed toxicities during six cycles, grade 3-4 thrombopenia was seen most frequently in group A. Neutropenia and subsequent interventions occurred more frequently in group A than ill group B. Subsequent interventions consisted of dose delays and reductions. When patients were treated for a longer duration of time with TMZ, grade 3-4 lymphopenia occurred significantly more often in group B, necessitating Pneumocystis carinii pneumonia prophylaxis. Conclusions: Degree of toxicity using a 5-day 200 mg/m(2) or 21-day 75 mg/m(2) schedule every four weeks was similar to that found in other studies. Implications for Nursing: Through awareness of toxicity in relation to knowledge of brain tumors, NPs can become more effective in active management of TMZ toxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
