| Autor: |
de Graaf-Roelfsema, E., Back, W., Keizer, H.A., Stout, T.A.E., van der Kolk, J.H., Advances in Veterinary Medicine, Dep Gezondheidszorg Paard |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Veterinary Record, 165(13), 373. British Veterinary Association |
| ISSN: |
0042-4900 |
| Popis: |
Serial blood samples were collected from three dwarf Friesian foals to examine their endogenous growth hormone (GH) profiles, and the integrity of the GH-insulin-like growth factor-1 (IGF-1) axis was tested in one of them by examining its responses to the administration of GH-releasing hormone (GHRH) and to 10 days of treatment with recombinant equine GH. The basal serum concentrations of IGF-1 in the three dwarf foals were compared with those in nine age-matched normal foals. All the dwarf foals secreted endogenous GH. Stimulation with 7.0 microg/kg GHRH led to a 1400 per cent increase in plasma GH concentration in the dwarf foal tested, and 10 daily subcutaneous treatments with 20 microg/kg recombinant equine GH led to a 100 per cent increase in its serum IGF-1 concentration. The basal serum concentrations of IGF-1 in the dwarf foals were not significantly different from those of the normal foals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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