| Autor: |
WEYKAMP, CW, PENDERS, TJ, MUSKIET, FAJ, VANDERSLIK, W |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Lifestyle Medicine (LM) |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Clinical Chemistry, 41(1), 82-86. AMER ASSOC CLINICAL CHEMISTRY |
| ISSN: |
0009-9147 |
| Popis: |
We investigated the effect of calibration with lyophilized calibrators on whole-blood glycohemoglobin (glyHb) results. One hundred three laboratories, using 20 different methods, determined glyHb in two lyophilized calibrators and two whole-blood samples. For whole-blood samples with low (5%) and high (9%) glyHb percentages, respectively, calibration decreased overall interlaboratory variation (CV) from 16% to 9% and from 11% to 6% and decreased intermethod variation from 14% to 6% and from 12% to 5%. Forty-seven laboratories, using 14 different methods, determined mean glyHb percentages in self-selected groups of 10 nondiabetic volunteers each. With calibration their overall mean (2SD) was 5.0% (0.5%), very close to the 5.0% (0.3%) derived from the reference method used in the Diabetes Control and Complications Trial. In both experiments the Abbott IMx and Vision showed deviating results. We conclude that, irrespective of the analytical method used, calibration enables standardization of glyHb results, reference values, and interpretation criteria. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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