| Autor: |
ZAMAN, GJR, VERSANTVOORT, CHM, SMIT, JJM, EIJDEMS, EWHM, DEHAAS, M, SMITH, AJ, BROXTERMAN, HJ, MULDER, NH, DEVRIES, EGE, BAAS, F, BORST, P |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Cancer Research, 53(8), 1747-1750. AMER ASSOC CANCER RESEARCH |
| ISSN: |
0008-5472 |
| Popis: |
Human cells can become multidrug resistant (MDR) by an increase in the activity of the MDR1 P-glycoprotein or by other, as vet unknown mechanisms, referred to as non-P-glycoprotein mediated MDR (non-Pgp MDR). S. P. C. Cole et al. [Science (Washington DC), 258: 1650-1654, 1992] recently reported that in two cell lines non-Pgp MDR was associated with the overexpression of a new putative membrane transporter gene, MRP. Using an RNase protection assay we have analyzed the expression of MRP in non-Pgp MDR sublines of the human lung cancer cell lines SW-1573 (non-small cell lung cancer) and GLC4 (small cell lung cancer). In all of ten SW-1573 derived lines examined the MRP mRNA level was equal to that in the parental line, whereas MRP was 25-fold overexpressed in a resistant subline of GLC4. We conclude that overexpression of MRP cannot account for all forms of non-Pgp MDR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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