| Autor: |
Miller, Mark R, Raftis, Jennifer B, Langrish, Jeremy P, McLean, Steven G, Samutrtai, Pawitrabhorn, Connell, Shea P, Wilson, Simon, Vesey, Alex T, Fokkens, Paul H B, Boere, John A F, Krystek, Petra, Campbell, Colin J, Hadoke, Patrick W F, Donaldson, Ken, Cassee, Flemming R, Newby, David E, Duffin, Rodger, Mills, Nicholas L, LS IRAS EEPI Inhalatie Toxicologie, dIRAS RA-1 |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
ACS Nano, 11(5), 4542. American Chemical Society |
| ISSN: |
1936-0851 |
| Popis: |
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy. Healthy volunteers were exposed to nanoparticles by acute inhalation, followed by repeated sampling of blood and urine. Gold was detected in the blood and urine within 15 min to 24 h after exposure, and was still present 3 months after exposure. Levels were greater following inhalation of 5 nm (primary diameter) particles compared to 30 nm particles. Studies in mice demonstrated the accumulation in the blood and liver following pulmonary exposure to a broader size range of gold nanoparticles (2-200 nm primary diameter), with translocation markedly greater for particles |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
