| Autor: |
van Oijen, Martijn G. H., Barthélémy, Christine, Janssen, Marcel J. R., Joiris, Etienne, Peters, Wilbert H. M., Laheij, Robert J. F., Smits, Paul, Odou, Pascal, Jansen, Jan B. M. J. |
| Přispěvatelé: |
Oncology, APH - Amsterdam Public Health, Other Research, Coronel Institute of Occupational Health |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Zdroj: |
Pharmacology, 83(4), 237-242. S. Karger AG |
| ISSN: |
0031-7012 |
| Popis: |
Objective: To compare plasma concentrations of acetylsalicylic acid (ASA) and its metabolites between genetic polymorphisms in the gene encoding for UDP-glucuronosyltransferase 1A6 (UGT1A6), an enzyme involved in ASA metabolism. Methods: Five UGT1A6*1 and 4 UGT1A6*2 homozygote females were given 320 mg ASA once daily for 8 days. During the first and last day of treatment, several blood samples were taken over a 10-hour time period and analyzed for plasma levels of ASA and its main metabolites salicylic acid (SA) and salicyluric acid (SUA), using a validated HPLC method. The pharmacokinetic data were assessed with the Time Constant Approach and both genotypes were compared using the Mann-Whitney U test. Results: ASA and SUA showed similar pharmacokinetic parameters in the two UGT1A6 genotypes. However, pharmacokinetic parameters for SA differed significantly: the mean area under the pharmacokinetic curve for the UGT1A6*1 and UGT1A6*2 homozygotes was 136 and 94 mu g/ml.h ( p = 0.04), and median C(max) was 23 and 17 mu g/ml (p = 0.01), respectively. Conclusion: In females receiving ASA, the presence of the UGT1A6*2 compared to the UGT1A6*1 homozygote genotype is associated with lower plasma levels of SA, indicating faster pharmacokinetics. Copyright (C) 2009 S. Karger AG, Basel |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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