| Autor: |
de Metz, J., Hack, C. E., Romijn, J. A., Levi, M. [=Marcel M.], Out, T. A., ten Berge, I. J., Sauerwein, H. P. |
| Přispěvatelé: |
Other departments |
| Jazyk: |
angličtina |
| Rok vydání: |
2001 |
| Zdroj: |
European journal of clinical investigation, 31(6), 536-543. Wiley-Blackwell |
| ISSN: |
0014-2972 |
| Popis: |
BACKGROUND: It is suggested that interferon-gamma (IFN-gamma), like other cytokines, is a mediator in the host inflammatory response, which could be of importance in the pathophysiology of sepsis. The role of IFN-gamma in human host inflammatory responses, however, has not been studied. DESIGN: In a placebo-controlled trial we studied the acute effects of IFN-gamma administration on host inflammatory mediators in healthy men: i.e. the cytokine/chemokine cascade system, acute-phase proteins, activation markers of the innate cellular immunity and coagulation/fibrinolysis parameters. RESULTS: IFN-gamma increased plasma levels of interleukin-6 (IL-6), IL-8 and IFN-gamma-inducible protein-10 (IP-10) (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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