DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites

Autor:	Westerbeek, H. A., Mooi, W. J., Begg, C., Dessing, M., Balm, A. J.
Přispěvatelé:	Other departments
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	stomatognathic diseases
Zdroj:	European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), 249(3), 140-143. Springer Verlag
ISSN:	0937-4477
Popis:	Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements
Databáze:	OpenAIRE
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