| Autor: |
Trung, Nguyen Vinh, Jamrozy, Dorota, Matamoros, S. bastien, Carrique-Mas, Juan J., Mai, Ho Huynh, Hieu, Thai Quoc, Mai, Nguyen Thi Nhu, Wagenaar, Jaap A., Thwaites, Guy, Parkhill, Julian, Schultsz, Constance, Hoa, Ngo Thi |
| Přispěvatelé: |
Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, APH - Global Health |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of antimicrobial chemotherapy, 74(3), 561-570. Oxford University Press |
| ISSN: |
0305-7453 |
| Popis: |
Objectives: To investigate the risk of colonization with ESBL-producing Escherichia coli (ESBL-Ec) in humans in Vietnam associated with non-intensive chicken farming. Methods: Faecal samples from 204 randomly selected farmers and their chickens, and from 306 age- and sexmatched community-based individuals who did not raise poultry were collected. Antimicrobial usage in chickens and humans was assessed by medicine cabinet surveys.WGS was employed to obtain a high-resolution genomic comparison between ESBL-Ec isolated from humans and chickens. Results: The adjusted prevalence of ESBL-Ec colonization was 20.0%(95% CI 10.8%-29.1%) and 35.2%(95% CI 30.4%-40.1%) in chicken farms and humans in Vietnam, respectively. Colonization with ESBL-Ec in humans was associated with antimicrobial usage (OR=2.52, 95% CI=1.08-5.87) but not with involvement in chicken farming. blaCTX-M-55 was the most common ESBL-encoding gene in strains isolated from chickens (74.4%) compared with blaCTX-M-27 in human strains (47.0%). In 3 of 204 (1.5%) of the farms, identical ESBL genes were detected in ESBL-Ec isolated from farmers and their chickens. Genomic similarity indicating recent sharing of ESBL-Ec between chickens and farmers was found in only one of these farms. Conclusions: The integration of epidemiological and genomic data in this study has demonstrated a limited contribution of non-intensive chicken farming to ESBL-Ec colonization in humans in Vietnam and further emphasizes the importance of reducing antimicrobial usage in both human and animal host reservoirs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
