| Autor: |
Gehring, U., de Jongste, J.C., Kerkhof, M., Oldewening, M., Postma, D., van Strien, R.T., Wijga, A.H., Willers, S.M., Wolse, A., Gerritsen, J., Smit, H.A., Brunekreef, B., Humaan, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Allergy, 67(2), 248. Blackwell Publishing Ltd |
| ISSN: |
0105-4538 |
| Popis: |
Background: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. Methods: High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen–impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. Results: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. Conclusion: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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