| Autor: |
Menke-Pluymers, M. B. E., Seynaeve, C., van Geel, A. N., Klijn, J. G. M., Meijers-Heijboer, E. J., Eggermont, A. M. M. |
| Přispěvatelé: |
Human Genetics |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Nederlands tijdschrift voor geneeskunde, 149(48), 2663-2667. Bohn Stafleu van Loghum |
| ISSN: |
0028-2162 |
| Popis: |
Preventive surgical procedures for inherited risk of breast cancer Forwomen with a demonstrated BRCA1 or BRCA2 mutation, the cumulative risk of developing invasive breast cancer before the age of 70 years is about 50-85% and the risk of developing invasive epithelial ovarian cancer is 20-60%. Regular surveillance including physical examination and imaging is offered to mutation carriers and the options for risk-reducing surgery are discussed. Although bilateral prophylactic mastectomy is a drastic intervention, it significantly reduces the incidence of breast cancer. For mutation carriers with breast cancer, the decision to combine risk-reducing surgery with treatment is determined by the TNM stage of the disease. Prophylactic bi- or contralateral mastectomy after previous treatment for unilateral breast cancer reduces the incidence of contralateral breast cancer, but has no impact on survival. The complexity of the problem demands a multidisciplinary approach within the context of a family cancer clinic |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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