Contribution of tubular anion and cation secretion to residual renal function in chronic dialysis patients

Autor: van Olden, R. W., van Acker, B. A., Koomen, G. C., Krediet, R. T., Arisz, L.
Přispěvatelé: Other departments
Jazyk: angličtina
Rok vydání: 1998
Zdroj: Clinical nephrology, 49(3), 167-172. Dustri-Verlag Dr. Karl Feistle
ISSN: 0301-0430
Popis: The clearance of organic ions by the tubules may contribute to the removal of uremic waste products in dialysis patients. The renal excretion of an exogenous anion p-aminohippurate (PAH) was investigated in 10 peritoneal dialysis patients and 10 hemodialysis patients during one clearance period and compared with the clearance of creatinine (Ccr) and inulin (CIn). The clearance period was 24 hours in the peritoneal dialysis patients and one interdialytic interval of 3 days divided in 4 parts [CPA-D] in hemodialysis patients. In peritoneal dialysis patients the renal clearance of total PAH (median 14.3 ml/min, range 3.8-33.0) exceeded the CIN (median 3.2 ml/min, range 1.6-11.2, p < 0.005) and Ccr (median 4.0 ml/min, range 1.7-15.0, p < 0.005). A positive correlation was found between the tubular clearances of creatinine (cationic pathway) and of total PAH (anionic pathway, r: 0.72, p
Databáze: OpenAIRE