| Autor: |
Jongbloed, F, Meijers, R W J, IJzermans, J N M, Klaassen, R A, Dollé, M E T, van den Berg, S, Betjes, M G H, de Bruin, R W F, van der Harst, E, Litjens, N H R |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Popis: |
Obesity adversely affects health and is associated with subclinical systemic inflammation and features of accelerated aging, including the T-cell immune system. The presence of metabolic syndrome (MetS) may accelerate, while bariatric surgery might reverse these phenomena. To examine the effects of MetS and bariatric surgery on T-cell aging, we measured relative telomere length (RTL) and T-cell differentiation status in obese patients before and after bariatric surgery. WHO II/III classified obese patients scheduled for bariatric surgery were included: 41 without MetS and 67 with MetS. RTL and T-cell differentiation status were measured in circulating CD4 Thymic output, represented by numbers of CD31-expressing naive T cells, showed an age-related decline in patients with MetS. MetS significantly enhanced CD8 In obese patients, MetS results in attrition of RTL and accelerated T-cell differentiation. Bariatric surgery temporarily reverses these effects. These data suggest that MetS is a risk factor for accelerated aging of T cells and that MetS should be a more prominent factor in the decision making for eligibility for bariatric surgery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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