| Autor: |
Landewe-Cleuren, S., van Zwam, W.H., de Bruin, T.W.A., Haan, M. |
| Přispěvatelé: |
RS: NUTRIM School of Nutrition and Translational Research in Metabolism, MUMC+: DA BV Medisch Specialisten Radiologie (9), Interne Geneeskunde |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Zdroj: |
Nederlands Tijdschrift voor Geneeskunde, 144, 1903-1905. Bohn Stafleu van Loghum |
| ISSN: |
0028-2162 |
| Popis: |
[Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy] [Article in Dutch] Landewe-Cleuren S, van Zwam WH, de Bruin TW, de Haan M. Academisch Ziekenhuis, AZ Maastricht. Use of the oral antidiabetic drug metformin may cause lactic acidosis, a rare but life-threatening complication, especially in patients with renal function loss. Since intravenously administered iodide-containing contrast media may cause renal function disturbances precautions should be taken in metformin-treated patients for whom a radiological study with intravenous contrast media is considered. In diabetic patients who use metformin a serum creatinine concentration should be measured prior to the radiological study. If the serum creatinine is within normal limits (< 130 mumol/l), metformin can be continued and the examination performed. If the serum creatinine concentration is increased (> or = 130 mumol/l), metformin should be discontinued and replaced by another antidiabetic drug if necessary. The radiological procedure with intravenous contrast media should be postponed for 48 hours. If such a procedure cannot be postponed, additional measures to prevent lactic acidosis (hydration, monitoring of the renal function) should be taken. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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