| Autor: |
KLEIBEUKER, JH, WELBERG, JWM, MULDER, NH, VANDERMEER, R, CATS, A, LIMBURG, AJ, KREUMER, WMT, HARDONK, MJ, DEVRIES, EGE |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
British Jounal of Cancer, 67(3), 500-503. Nature Publishing Group |
| ISSN: |
0007-0920 |
| Popis: |
To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months without dietary restrictions. Epithelial proliferation rate in colonic biopsies, expressed as labelling index (%), was determined with 5-bromodeoxyuridine and immunohistochemistry. Biopsies were taken from the midsigmoid at time of polyp excision and at the end of the intervention period. Median labelling index increased from 6.1% before to 8.7% after 12 weeks calcium (n = 17, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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