| Autor: |
Jansen, HML, Paans, AMJ, Vliet, AMV, VeenmavanderDuin, L, BolwijnMeijer, CJW, Pruim, J, Willemsen, ATM, Franssen, EJF, Minderhoud, JM, Korf, J |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Clinical neurology and neurosurgery, 99(1), 6-10. ELSEVIER SCIENCE BV |
| ISSN: |
0303-8467 |
| Popis: |
After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Go) as a Ga-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Go-PET may have prognostic value in stroke. Six stroke patients were examined with Go-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient? specific Go-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Go-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary. (C) 1997 Elsevier Science B.V. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect