Gastric non-Hodgkin lymphomas of mucosa-associated lymphoid tissue are not associated with more aggressive Helicobacter pylori strains as identified by CagA

Autor: de Jong, D., van der Hulst, R. W., Pals, G., van Dijk, W. C., van der Ende, A., Tytgat, G. N., Taal, B. G., Boot, H.
Přispěvatelé: Other departments
Jazyk: angličtina
Rok vydání: 1996
Předmět:
Zdroj: American journal of clinical pathology, 106(5), 670-675. American Society of Clinical Pathologists
ISSN: 0002-9173
Popis: Primary gastric non-Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT-NHL) is strongly related to Helicobacter pylori (H pylori) infection. CagA positive H pylori strains appear to be more aggressive, as reflected by a greater degree of gastric inflammation and higher levels of Il-8 production. Using a polymerase chain reaction-based assay, cagA status was determined in H pylori strains of 12 patients with gastric MALT-NHL, 38 patients with peptic ulcer disease, and 39 patients with non-ulcer dyspepsia. CagA-positive H pylori strains were significantly more frequent in peptic ulcer disease than in non-ulcer dyspepsia (Fisher's exact test p
Databáze: OpenAIRE