Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease
| Autor: | de Wal, R. M. A. van, van der Harst, P., Wassmann, S., Morshuis, W. J., Nickenig, G., Buikema, H., Plokker, H. W. M., van Veldhuisen, D. J., van Gilst, W. H., Voors, A. A. |
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| Přispěvatelé: | Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
IDENTIFICATION
human artery BLOOD-PRESSURE AT(2) RECEPTOR angiotensin II MESENTERIC-ARTERIES phenylephrine SUBTYPES angiotensin II receptors cardiovascular system isotonic experiments vasoconstriction HYPERTENSIVE-RATS vasodilation hormones hormone substitutes and hormone antagonists SYSTEM AT2-RECEPTOR |
| Zdroj: | Journal of Cardiovascular Pharmacology, 50(4), 372-379 |
| ISSN: | 0160-2446 |
| Popis: | Background: Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the vasotonus of human internal mammary arteries. Methods: Internal mammary arteries were obtained from 50 patients undergoing coronary bypass surgery. The expression of angiotensin II type I (AT1) receptor and AT2 receptor mRNA was determined by using real-time polymerase chain reaction. In addition, angiotensin II and CGP42112A concentration-response curves (concentration range: 10(-10) M to 10(-6) M) were constructed in absence or presence of candesartan (10(-5) M) and/or the AT2 receptor-antagonist PD-123319 (10-6 M) and/or the a receptor antagonist phentolamine. Results: Both AT1 and AT2 receptor protein and mRNA were detected, and higher AT2 receptor mRNA expression levels were associated with increased contractile response to angiotensin II. Angiotensin II caused vasoconstriction up to 41.1 +/- 6.5% of the maximal response to phenylephrine, and PD123319 significantly reduced this response (28.6 +/- 9.6%, P |
| Databáze: | OpenAIRE |
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