Collection of hematopoietic stem cells from patients with autoimmune diseases
| Autor: | Burt, RK, Fassas, A, Snowden, JA, Kozak, T, Wulffraat, NM, Nash, RA, Dunbar, CE, Arnold, R, Prentice, G, Bingham, S, Marmont, AM, McSweeney, PA, van Laar, J.M. |
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| Přispěvatelé: | University of Groningen |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
PROGENITOR CELLS
hematopoietic stem cell transplantation autoimmune disease PROGRESSIVE MULTIPLE-SCLEROSIS SYSTEMIC-LUPUS-ERYTHEMATOSUS COLONY-STIMULATING FACTOR DOSE IMMUNOSUPPRESSIVE THERAPY G-CSF ACTIVE RHEUMATOID-ARTHRITIS mobilization PERIPHERAL-BLOOD STEM BONE-MARROW-TRANSPLANTATION DENDRITIC CELLS |
| Zdroj: | Bone marrow transplantation, 28(1), 1-12. Nature Publishing Group |
| ISSN: | 0268-3369 |
| Popis: | We reviewed data from 24 transplant centers in Asia, Australia, Europe, and North America to determine the outcomes of stem cell collection including methods used, cell yields, effects on disease activity, and complications in patients with autoimmune diseases. Twenty-one unprimed bone marrow harvests and 174 peripheral blood stem cell mobilizations were performed on 187 patients. Disease indications were multiple sclerosis (76 patients), rheumatoid arthritis (37 patients), scleroderma (26 patients), systemic lupus erythematosus (19 patients), juvenile chronic arthritis (13 patients), idiopathic autoimmune thrombocytopenia (8 patients), Behcet's disease (3 patients), undifferentiated vasculitis (3 patients), polychondritis (1 patient) and polymyositis (1 patient). Bone marrow harvests were used in the Peoples Republic of China and preferred worldwide for children. PBSC mobilization was the preferred technique for adult stem cell collection in America, Australia, and Europe. Methods of PBSC mobilization included G-CSF (5, 10, or 16 mug/kg/day) or cyclophosphamide (2 or 4 g/m(2)) with either G-CSF (5 or 10 mug/kg/day) or GM-CSF (5 mug/kg/day). Bone marrow harvests were without complications and did not affect disease activity. A combination of cyclophosphamide and G-CSF was more likely to ameliorate disease activity than G-CSF alone (P |
| Databáze: | OpenAIRE |
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