| Autor: |
Prata, M.I.M., Ribeiro, M.J., Santos, A.C., Peters, J.A., Nepveu, F., Geraldes, C.F.G.C., De Lima, J.J.P. |
| Jazyk: |
angličtina |
| Rok vydání: |
1998 |
| Zdroj: |
Metal-Based Drugs, 5 (5) |
| ISSN: |
1687-5486 |
| Popis: |
Aiming at radiopharmaceutical application, I111n3+ complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of I111n(TTHA)3- and I111n(TTHA-bis(butylamide)- was evaluated by measuring the exchange of I111n3+ from the complexes to transferrin and the results were compared with those for I111n(DTPA)2-. We also performed biodistribution studies of the three I111n3+ complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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