| Autor: |
Fiebrich, H. -B., van den Berg, G., Kema, I. P., Links, T. P., Kleibeuker, J. H., van Beek, A. P., Walenkamp, A. M. E., Sluiter, W. J., de Vries, E. G. E. |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Alimentary Pharmacology & Therapeutics, 32(11-12), 1398-1404. Wiley |
| ISSN: |
0269-2813 |
| Popis: |
P>Background Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels remains unknown. Aim To investigate the prevalence of fat-soluble vitamin deficiencies in long-term somatostatin analogue users. Methods All acromegaly and carcinoid patients using somatostatin analogues for >= 18 months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat-soluble vitamins in blood, clinical and vitamin-dependent laboratory parameters were collected. Results In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty-two (78%) were deficient for one or more vitamins, and 32% (n = 17) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels. Conclusions Fat-soluble vitamin deficiencies are frequent during long-term somatostatin analogue treatment. Therefore, fat-soluble vitamins should be monitored in these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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