| Autor: |
van Lopik, T, Bijl, M, Hart, M, Boeije, L, Gesner, T, Creasy, AA, Kallenberg, CGM, Aarden, LA, Smeenk, RJT, Smeenk, JT |
| Přispěvatelé: |
Translational Immunology Groningen (TRIGR) |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Journal of Rheumatology, 26(1), 60-67. J RHEUMATOL PUBL CO |
| ISSN: |
0315-162X |
| Popis: |
Objective. We related soluble Fas (sFas) levels to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) in a longitudinal series of plasma samples of patients with SLE to evaluate the relation between excessive production of sFas and disease activity. Methods. We generated 21 monoclonal antibodies against Fas. Two Of these were used to develop and validate a sensitive sandwich ELISA for the longitudinal analysis of sFas levels in plasma of 30 patients and 25 controls. Results. At the start of followup, a significant elevation (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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