C-Reactive protein and cardiac troponin T in risk stratification: differences in optimal timing of tests early after the onset of chest pain

Autor: de Winter, R. J., Fischer, J., Bholasingh, R., van Straalen, J. P., de Jong, T., Tijssen, J. G., Sanders, G. T.
Přispěvatelé: Other departments
Jazyk: angličtina
Rok vydání: 2000
Zdroj: Clinical chemistry, 46(10), 1597-1603. American Association for Clinical Chemistry Inc.
ISSN: 0009-9147
Popis: BACKGROUND: Increased C-reactive protein (CRP) is an important prognostic indicator for early risk stratification in patients with an acute coronary syndrome (ACS), independent of, and in combination with, increased cardiac troponin T (cTnT). However, increases in both cTnT and CRP also occur secondary to myocardial damage. METHODS AND RESULTS: In 156 consecutive patients, early release kinetics of CRP and cTnT were analyzed. The cutoff values were 3.0 mg/L for CRP and 0.1 microgram/L for cTnT. In the 75 patients with a CRP below the cutoff on admission, there was little change in CRP until 8 h after the onset of symptoms. At 12 h after the onset of symptoms, the cumulative proportions of abnormal CRP and cTnT in non-ST elevation ACS patients were 27% and 89%, respectively (P
Databáze: OpenAIRE