| Autor: |
Peters, FTM, Kuipers, EJ, Ganesh, S, Sluiter, WJ, Klinkenberg-Knol, EC, Lamers, CBHW, Kleibeuker, JH |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Alimentary Pharmacology & Therapeutics, 13(7), 921-926. Wiley |
| ISSN: |
0269-2813 |
| Popis: |
Background: Helicobacter pylori exaggerates the effect of acid suppressive drugs on intragastric pH. It is unknown whether this is relevant for the treatment of GERD. Aim: To compare oesophageal acid exposure and symptoms in H. pylori-negative and H. pylori-positive GERD patients during low and profound acid suppression. Methods: Barrett's oesophagus patients with gastro-oesophageal acid reflux were studied by 24-h oesophageal pH-metry at baseline and during randomized treatment with omeprazole 40 mg b.d. or ranitidine 150 mg b.d. a pylori status was determined by a serum IgG ELISA. Symptoms were scored on a four-graded scale. Results: Of 58 patients, 26 (14 H. pylori-negative, 12 H. pylori-positive) were randomized to omeprazole, 32 (16 H. pylori-negative, 16 H. pylori-positive) to ranitidine. At baseline, oesophageal acid exposure and symptoms did not differ between H. pylori-negative and H. pylori-positive: mean time proportion pH |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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