PRENATAL EXPOSURE TO PHENYTOIN, FACIAL DEVELOPMENT, AND A POSSIBLE ROLE FOR VITAMIN-K
| Autor: | HOWE, AM, LIPSON, AH, SHEFFIELD, LJ, HAAN, EA, HALLIDAY, JL, JENSON, F, DAVID, DJ, WEBSTER, WS |
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| Přispěvatelé: | University of Groningen |
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
BINDER SYNDROME
VITAMIN-K DEFICIENCY FETAL HYDANTOIN SYNDROME HEMORRHAGIC-DISEASE EMBRYOPATHY WARFARIN PHENYTOIN TERATOGENICITY PLACENTAL-TRANSFER MINOR ANOMALIES PREGNANCY MATERNAL ANTICONVULSANT THERAPY BIRTH-DEFECTS HYDANTOIN PHENOBARBITONE ANTICONVULSANTS CHONDRODYSPLASIA PUNCTATA WARFARIN EMBRYOPATHY |
| Zdroj: | American Journal of Medical Genetics, 58(3), 238-244. WILEY-LISS |
| ISSN: | 0148-7299 |
| Popis: | Ten patients with maxillonasal hypoplasia (Binder ''syndrome''), who were prenatally exposed to phenytoin (usually in combination with other anticonvulsants), were identified retrospectively. In addition to their facial anomalies, 6 of the patients were radiographed neonatally and showed punctate calcification, characteristic of chondrodysplasia punctata. Evidence is presented that the facial abnormalities seen in these children are due to anticonvulsant-induced vitamin K deficiency, causing abnormal development of the cartilaginous nasal septun. We propose that early vitamin K supplementation of at-risk pregnancies may prevent the development of maxillonasal hypoplasia, which in some patients is severely disfiguring and causes great emotional distress. Correction of this facial defect requires surgical and dental treatment over a long period of time. (C) 1995 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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