| Autor: |
Martin, Daniel S., Goedhart, Peter, Vercueil, Andre, Ince, Can, Levett, Denny Z. H., Grocott, Mike P. W. |
| Přispěvatelé: |
Biomedical Engineering and Physics, ACS - Amsterdam Cardiovascular Sciences, Translational Physiology |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Zdroj: |
Experimental physiology, 95(8), 880-891. Wiley-Blackwell |
| ISSN: |
0958-0670 |
| Popis: |
We hypothesized that ascent to altitude would result in reduced sublingual microcirculatory flow index (MFI) and increased vessel density. Twenty-four subjects were studied using sidestream dark-field imaging, as they ascended to 5300 m; one cohort remained at this altitude (n = 10), while another ascended higher (maximum 8848 m; n = 14). The MFI, vessel density and grid crossings (GX; an alternative density measure) were calculated. Total study length was 71 days; images were recorded at sea level (SL), Namche Bazaar (3500 m), Everest base camp (5300 m), the Western Cwm (6400 m), South Col (7950 m) and departure from Everest base camp (5300 m; 5300 m-b). Peripheral oxygen saturation (S-pO2), heart rate and blood pressure were also recorded. Compared with SL, altitude resulted in reduced sublingual MFI in small ( 25 mu m rose from 1.68 (+/- 0.43) mm mm-2 at SL to 2.27 (+/- 0.57) mm mm-2 at 5300 m-b (P = 0.005); GX increased at all altitudes (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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