| Autor: |
Peters, FTM, Ganesh, S, Kuipers, EJ, De Jager-Krikken, A, Karrenbeld, A, Harms, Geert, Sluiter, WJ, Koudstaal, J, Klinkenberg-Knol, EC, Lamers, CBHW, Kleibeuker, JH |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Digestive Diseases and Sciences, 43(7), 1501-1506. SPRINGER |
| ISSN: |
0163-2116 |
| Popis: |
Barrett's esophagus (BE) is a premalignant condition, due to chronic gastroesophageal reflux. Effective antireflux therapy may diminish cancer risk. To evaluate this option an intermediate marker is needed. We developed a methodology for measurement of epithelial cell proliferative activity of Barrett's mucosa as an intermediate marker and correlated the activity with traditional cancer risk markers and other parameters. Fifty-six patients (21-74 years of age) with Barrett's esophagus and established acid gastroesophageal reflux were included. Biopsies were taken from Barrett's mucosa at 3-cm intervals. Reflux was measured by 24-hr pH-metry. Proliferative activity was determined using in vitro labeling with 5-bromodeoxyuridine and immunohistochemistry and was expressed as labeling index (LI). The length of BE correlated with erect acid reflux (P = 0.002). LI in specialized columnar metaplasia was higher than in gastric metaplasia, especially in crypt epithelium (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink