The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects

Autor: Bakker, SJL, ter Maaten, JC, Popp-Snijders, C, Slaets, JPJ, Heine, RJ, Gans, ROB
Přispěvatelé: Health Psychology Research (HPR), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC)
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Zdroj: Journal of Clinical Endocrinology and Metabolism, 86(3), 1206-1211. ENDOCRINE SOC
ISSN: 0021-972X
Popis: High levels of TSH are associated with an increased cardiovascular risk. Many cardiovascular risk factors cluster within the insulin resistance syndrome. It is not known whether levels of TSH cluster as well. We conducted this research to test the hypothesis that TSH, insulin sensitivity, and levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) are interdependent in euthyroid subjects. Levels of TSH, free thyroid hormone, and serum Lipids were measured in fasting serum samples taken before performance of a hyperinsulinemic euglycemic clamp to assess insulin sensitivity in 46 healthy euthyroid subjects with a mean TSH of 1.8 +- 0.7 mU/L. Significant age- and sex-adjusted partial correlations of TSH with LDL-C (r = 0.48; P
Databáze: OpenAIRE