| Autor: |
Vermeire TG, Stevenson H, Pieters MN, Rennen M, Slob W, Hakkert BC, Nederlandse organisatie voor toegepast wetenschappelijk onderzoek (TNO), Zeist, CSR, LEO, TNO-ITV |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Popis: |
The general goal of this discussion paper is to contribute towards further harmonisation of the human health risk assessment. It discusses the development of a formal, harmonised set of default assessment factors. The status quo with regard to assessment factors is reviewed. Options are presented for a set of default values or probabilistic distributions for assessment factors based on the state of the art. Methods of combining default values or probabilistic distributions of assessment factors are described. The benchmark dose concept is proposed for better characterisation of the true human no-effect level in a probabilistic manner. It is shown how the probabilistic benchmark dose distribution can be combined with distributions of assessment factors to arrive at the distribution of a Human Limit Value. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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