| Autor: |
Janssen, JAMJL, Koper, JW, Stolk, RP, Englaro, P, Uitterlinden, AG, Huang, Q, van Leeuwen, JPTM, Blum, WF, Attanasio, AMF, Pols, HAP, Grobbee, DE, de Jong, FH, Lamberts, SWJ |
| Přispěvatelé: |
Life Course Epidemiology (LCE), Lifestyle Medicine (LM) |
| Jazyk: |
angličtina |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Clinical Endocrinology, 49(2), 229-234. Wiley |
| ISSN: |
0300-0664 |
| Popis: |
BACKGROUND The associations between leptin levels and the prevalence of a polymorphism in the beta(3)-adrenergic receptor were studied in a cross-sectional analysis of 600 participants in a population-based study, which were stratified for glucose tolerance by an oral glucose tolerance test. METHODS In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the beta(3)-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome. RESULTS Mean age of the study population was 66.9 years (SD 5.7). Fasting serum leptin levels overall in men and women were 6.1 mu g/l (SE 0.2) and 21.7 mu g/l (0.9), respectively, (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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