| Autor: |
Maarschalk, KV, Vromans, H, Bolhuis, GK, Lerk, CF |
| Přispěvatelé: |
Pharmaceutical Technology and Biopharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD) |
| Jazyk: |
angličtina |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
European Journal of Pharmaceutics and Biopharmaceutics, 42(1), 49-55. ELSEVIER SCIENCE BV |
| ISSN: |
0939-6411 |
| Popis: |
This paper evalutes the applicability of Dynamic Mechanical Analysis (DMA) as a tool to explain consolidation and relaxation behaviour of a viscoelastic powder compressed at different speeds. From the DMA-data it is concluded that the material becomes more rigid and more elastic with increasing deformation rates. Compaction of the material at low speed resulted in the formation of tablets with low porosity. This effect is caused by the dominant viscous component, which results in irreversible deformation. Compaction at high speed produced tablets with a higher porosity and a lower strength. This effect is caused by an increased elasticity which results in a considerable volume increase after compression. The tablet porosity after ejection is influenced by both compression and decompression speed. There is, however, a threshold above which the compression speed did not influence tablet porosity. This is in agreement with DMA data, where a limiting value of the viscoelasticity was found at a comparable frequency. In contrast, decompression speed influenced tablet porosity at any compaction speed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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