| Autor: |
Heijckmann, A. Caroline, Huijberts, Maya S. P., De Vries, Jolanda, Menheere, Paul P. C. A., Van der Veer, Eveline, Kruseman, Arie C. Nieuwenhuijzen, Wolffenbuttel, Bruce H. R., Geusens, Piet, Drent, Marjolein |
| Přispěvatelé: |
Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Translational Immunology Groningen (TRIGR), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Sarcoidosis Vasculitis and Diffuse Lung Diseases, 24(1), 51-58 |
| ISSN: |
1124-0490 |
| Popis: |
Background and aim of the work: Sarcoidosis is a chronic inflammatory T-cell-driven disease can also affect bone. We evaluated bone remodelling and bone mineral density (BMD) in patients with coidosis and their dependency of disease-related and treatment-related factors. Methods: In 124 BMD of the hip (DXA) and markers of bone resorption (ICTP) and formation (PINP) were evaluated. thermore a lateral DXA of the spine for morphometric assessment of vertebral deformities was performed 87 patients. Potential predictors of bone markers, BMD and determinants of prevalent vertebral were assessed using multiple and logistic regression analysis. Results: The population studied comprised treated patients (n = 51), patients that previously used glucocorticoids (n = 31) and patients currently glucocorticoids (n = 42). In all these groups the age- and gender corrected Z-scores of the hip were except in untreated patients, which revealed an increased Z-score at the trochanter (p = 0.004). In all but patients currently on glucocorticoids the Z-scores for PINP and ICTP were increased (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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