Characterization of post-transplant lymphoproliferative disorder with semi-quantitative FDG-PET/CT
| Autor: | Montes De Jesus, F., Noordzij, W., Kahle, X., Nijland, M., Verschuuren, E., Dierckx, R., Van Der Meerten, T., Van Der Bij, W., Huls, G., Kwee, T., Glaudemans, A. |
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| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Translational Immunology Groningen (TRIGR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Groningen Institute for Organ Transplantation (GIOT) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
cancer patient
clinical article posttransplant lymphoproliferative disease conference abstract quantitative analysis software adult human cell practice guideline immunosuppressive treatment lymph node PET-CT scanner surgical procedures operative classical Hodgkin lymphoma female peak standardized uptake value male hemic and lymphatic diseases histopathology positron emission tomography-computed tomography controlled study maximum standardized uptake value human mean standardized uptake value |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging, 46(1). SPRINGER |
| ISSN: | 1619-7070 |
| Popis: | Aim/Introduction: One of the most dire complications of hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) is the development of post-transplant lymphoproliferative disorder (PTLD). PTLD compromises a broad spectrum of disorders classified by the 2017 World Health Organization (WHO) in non-destructive, polymorphic, monomorphic and classic Hodgkin lymphoma. Distinct morphologies are associated with a more favorable clinical course and better response to initial treatment. Reduction of immunosuppression, commonly used as first-line treatment, has been associated with higher response rates in non-destructive and polymorphic PTLD, while a more aggressive therapy is advised for monomorphic PTLD. Biopsy is the reference standard for PTLD diagnosis and classification, but may not always be safely possible. Therefore, there is a need for non-invasive imaging-based tools. Materials and Methods: All patients with histopathologically proven PTLD at the UMC Groningen were included in this study between January 2010 to March 2019. FDG-PET/CT scans were performed on a Siemens Biograph mCT camera, according to EANM procedure guidelines for tumor imaging and reconstruction parameters compliant with EARL recommendations. Semi-quantitative measurements (SUVmax, SUVpeak and SUVmean) were performed using dedicated Hermes Hybrid 3D software with the ?Tumor Finder? application. Semi-quantitative measurements were obtained from the biopsy site or in cases in which a biopsy was performed before the scan from the nearest lymph node in the same lymph node region Results: In total 41 patients were included. From those, 27 were monomorphic PTLD and 14 were ?other PTLD morphologies?, including non-destructive (n=4), polymorphic (n=9) and Hodgkin-like PTLD (n=1). Median SUVmax, SUVpeak, SUVmean values were statistically significantly higher in monomorphic PTLD than in ?other PTLD morphologies (p |
| Databáze: | OpenAIRE |
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