| Autor: |
VANVELDHUISEN, DJ, BRODDE, OE, VANGILST, WH, SCHULZE, C, ANTHONIO, RL, DEGRAEFF, PA, WESSELING, H, LIE, KI |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Cardiovascular Centre (CVC) |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Cardiovascular Research, 30(3), 386-393. Oxford University Press |
| ISSN: |
0008-6363 |
| Popis: |
Objectives: The purpose of this study was to investigate the changes in beta-adrenoceptor density (B-max) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopamine and captopril. Methods: There were 3 experiments: (1) B-max and plasma catecholamines were examined (n = 46), (2) B-max was compared in infarcted and non-infarcted tissue (n = 13), and (3) contractile function was evaluated by isolated heart perfusion (n = 40). Of rats in Expts. (1) and (3), 50% had myocardial infarction induced by coronary ligation and 50% were controls. Each group was divided between ibopamine, ibopamine and captopril, or standard (no drug) treatment. Results: B-max was not decreased in rats with myocardial infarction (10.8 +/- 0.8 fmol/mg protein), compared to normal rats (11.4 +/- 0.6 fmol/mg protein), and the ratio beta(1)/beta(2) was also unaffected. In infarcted tissue, B-max was significantly (P = 0.03) lower than in non-infarcted tissue. Baseline left ventricular pressure, systolic and diastolic dP/dT were all impaired (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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